Lack of consistent sex differences in d-amphetamine-induced dopamine release measured with [18F]fallypride PET
| Autor: | Christopher T. Smith, Linh C. Dang, Leah L. Burgess, David H. Zald, Darcy K. Smith, Ronald L. Cowan, Scott F. Perkins, Nam T. Le, Gregory R. Samanez-Larkin, Robert M. Kessler, M. Danica San Juan |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Fluorine Radioisotopes medicine.medical_specialty Dextroamphetamine Dopamine media_common.quotation_subject Placebo Article Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Dopamine receptor D2 Internal medicine medicine Humans Young adult Amphetamine Menstrual cycle Aged media_common Pharmacology Sex Characteristics Receptors Dopamine D2 business.industry Dopaminergic Receptors Dopamine D3 Middle Aged 030227 psychiatry Endocrinology Fallypride Positron-Emission Tomography Benzamides Ventral Striatum Central Nervous System Stimulants Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychopharmacology. 236:581-590 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | RATIONALE: Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES: Here, we sought to investigate sex differences in dopamine release after oral d-amphetamine administration. METHODS: We used [(18)F]fallypride Positron Emission Tomography (PET) to measure the change in dopamine D2/3 receptor availability (%ΔBP(ND), an index of dopamine release) between placebo and d-amphetamine sessions in two independent datasets containing a total of 39 females (either on hormonal birth control n=18, postmenopausal n=10, or studied in the first 10 days of their menstrual cycle n=11) and 37 males. RESULTS: Using both a priori anatomical regions of interest based on previous findings as well as voxelwise analyses, we failed to consistently detect broad sex differences in d-amphetamine-induced dopamine release. Nevertheless, there was limited evidence for greater right ventral striatal dopamine release in young adult males relative to similarly aged females, but this was not consistently observed across samples. Plasma estradiol did not correlate with dopamine release and this measure did not differ in females on and off hormonal birth control. CONCLUSIONS: While our finding in young adults from one dataset of greater %ΔBP(ND) in males is partially consistent with a previously published study on sex differences in d-amphetamine-induced dopamine release, our data do not support the presence of consistent widespread sex differences in this measure of dopamine release. |
| Databáze: | OpenAIRE |
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