Lipids of the oligodendroglial fraction in methylnitrosourea induced encephalopathy
| Autor: | Z. Adamczewska-Goncerzewicz, A. Goncerzewicz, Pankrac J, M. Wender, D. Talkowska |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Encephalopathy Central nervous system Nerve Tissue Proteins Fraction (chemistry) Biology Nitrosourea Compounds Pathology and Forensic Medicine chemistry.chemical_compound Myelin Internal medicine medicine Animals Brain Diseases Cerebral white matter Methylnitrosourea Rats Inbred Strains Lipid metabolism Phosphatidylserine medicine.disease Lipids Rats Oligodendroglia Endocrinology medicine.anatomical_structure Biochemistry chemistry Sphingomyelin Neuroglia |
| Zdroj: | Experimental pathology. 20:64-67 |
| ISSN: | 0232-1513 |
| Popis: | Summary The investigations were performed on oligodendroglial cells isolated from the cerebral white matter of Wistar rats treated intravenously with a 3% solution of MNU at a dose of 60 mg/ kg body weight. The oligodendroglial fraction showed a decrease of the sphingomyelin, phosphatidylserine and phosphoinositides content. The observed changes correlated with alterations of the lipid spectrum found in the myelin fraction of MNU intoxicated rats. This would indicate that MNU acting in the central nervous system affects in a similar way the lipid metabolism of both components of the oligodendroglia-myelin system. |
| Databáze: | OpenAIRE |
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