Foetal, neonatal and child vitamin D status and enamel hypomineralization

Autor: Eppo B. Wolvius, Josje D. Schoufour, M.E.C. Elfrink, Annemieke C. Heijboer, Trudy Voortman, Justin T. van der Tas, Edwin M. Ongkosuwito, Henning Tiemeier, Fernando Rivadeneira, Henriette A. Moll, Vincent W. V. Jaddoe
Přispěvatelé: Laboratory Medicine, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Movement Sciences - Rehabilitation & Development, NCA - Brain mechanisms in health and disease, Erasmus MC other, Oral and Maxillofacial Surgery, Epidemiology, Internal Medicine, Pediatrics, Child and Adolescent Psychiatry / Psychology, Psychiatry
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
25‐hydroxyvitamin D
Umbilical cord
paediatric dentistry
risk prediction
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
permanent dentition
primary dentition
Epidemiology
medicine
Vitamin D and neurology
Humans
030212 general & internal medicine
Vitamin D
Child
enamel biomineralization/formation
Prospective cohort study
General Dentistry
2. Zero hunger
business.industry
Obstetrics
Confounding
Infant
Newborn
Public Health
Environmental and Occupational Health
Original Articles
030206 dentistry
Fetal Blood
Molar Incisor Hypomineralization
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
medicine.anatomical_structure
In utero
Child
Preschool
Dental Enamel Hypoplasia
Female
Original Article
epidemiology
Generation R
business
Zdroj: van der Tas, J T, Elfrink, M E C, Heijboer, A C, Rivadeneira, F, Jaddoe, V W V, Tiemeier, H, Schoufour, J D, Moll, H A, Ongkosuwito, E M, Wolvius, E B & Voortman, T 2018, ' Foetal, neonatal and child vitamin D status and enamel hypomineralization ', Community Dentistry and Oral Epidemiology, vol. 46, no. 4, pp. 343-351 . https://doi.org/10.1111/cdoe.12372
Community Dentistry and Oral Epidemiology, 46, 4, pp. 343-351
Community Dentistry and Oral Epidemiology, 46(4), 343-351. Blackwell Munksgaard
Community Dentistry and Oral Epidemiology, 46(4), 343-351. Blackwell Publishing
Community Dentistry and Oral Epidemiology
Community Dentistry and Oral Epidemiology, 46, 343-351
ISSN: 0301-5661
DOI: 10.1111/cdoe.12372
Popis: Contains fulltext : 196219.pdf (Publisher’s version ) (Open Access) OBJECTIVES: Recent literature suggested that higher vitamin D concentrations in childhood are associated with a lower prevalence of molar incisor hypomineralization (MIH). As tooth development already starts in utero, we aimed to study whether vitamin D status during foetal, postnatal and childhood periods is associated with the presence of hypomineralized second primary molars (HSPMs) and/or MIH at the age of six. METHODS: Our study was embedded in the Generation R Study, a population-based, prospective cohort from foetal life onwards in Rotterdam, the Netherlands. HSPMs and MIH were scored from intraoral photographs of the children at their age of six. Serum 25(OH)D concentrations were measured at three points in time, which resulted in three different samples; mid-gestational in mothers' blood (n = 4750), in umbilical cord blood (n = 3406) and in children's blood at the age of 6 years (n = 3983). RESULTS: The children had a mean (+/-SD) age of 6.2 (+/-0.5) years at the moment of taking the intraoral photographs. After adjustment for confounders, no association was found between foetal 25(OH)D concentrations and the presence of HSPMs (OR 1.02 per 10 nmol/L higher 25(OH)D, 95% CI: 0.98-1.07) or MIH (OR 1.05 per 10 nmol/L increase, 95% CI: 0.98-1.12) in 6-year-olds. A higher 25(OH)D concentration in umbilical cord blood resulted in neither lower odds of having HSPM (OR 1.05, 95% CI: 0.98-1.13) nor lower odds of having MIH (OR 0.95, 95% CI: 0.84-1.07) by the age of six. Finally, we did not find higher 25(OH)D concentrations at the age of six to be associated with a significant change in the odds of having HSPM (OR 0.97, 95% CI: 0.92-1.02) or MIH (OR 1.07, 95% CI: 0.98-1.16). CONCLUSIONS: 25(OH)D concentrations in prenatal, early postnatal and later postnatal life are not associated with the presence of HPSMs or with MIH at the age of six. Future observational research is required to replicate our findings. Furthermore, it is encouraged to focus on identifying other modifiable risk factors, because prevention of hypomineralization is possible only if the causes are known. 01 augustus 2018
Databáze: OpenAIRE
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