Local immune responses to influenza antigen are synergistically enhanced by the adjuvant ISCOMATRIX
| Autor: | Jan M. Tennent, Lorraine Beezum, Alan Coulter, J-P.Y. Scheerlinck, Peter McWaters, Wayne G. Kimpton, Martin J. Pearse, R.G. Windon, Anders Sjölander, Ross N. P. Cahill, Paul J. Chaplin, Debbie Drane, M. Tzatzaris, M. Tavarnesi |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_treatment
Lymphocyte Biology Antibodies Viral Lymphocyte Activation Immune system Virus antigen Antigen Adjuvants Immunologic medicine Animals Lymph node Antigens Viral Sheep General Veterinary General Immunology and Microbiology Interleukin-6 Lymph duct Public Health Environmental and Occupational Health Orthomyxoviridae Infectious Diseases medicine.anatomical_structure Immunology Molecular Medicine Cytokines Viral disease Adjuvant ISCOMs |
| Zdroj: | Vaccine. 20(3-4) |
| ISSN: | 0264-410X |
| Popis: | The peripheral (draining) lymph node, as the primary site of immune induction, determines the course of systemic responses to an injected antigen. Lymphatic duct cannulation procedures in sheep were used to investigate local immunoreactivity to human influenza virus antigen (Flu ag) admixed with the adjuvant ISCOMATRIX® (IMX). Compared to Flu ag or IMX alone, the co-administration of Flu ag and IMX (Flu ag+IMX) synergistically enhanced a number of immunological responses (lymphocyte and blast migration from the node, antigen-specific antibody levels and IL6 output in efferent lymph, and antigen-induced proliferation in cultured efferent lymph cells). Together, these results demonstrate that IMX is an immune modulator, and that lymphatic duct cannulation procedures may be used to evaluate antigen/adjuvant combinations for vaccine development. |
| Databáze: | OpenAIRE |
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