Combined proton-photon treatment for breast cancer
| Autor: | Antony J. Lomax, Louise Marc, Silvia Fabiano, C. Linsenmeier, Jan Unkelbach, Niklas Wahl |
|---|---|
| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Photon
Proton Planning target volume Breast Neoplasms 610 Medicine & health Linear particle accelerator breast cancer Breast cancer medicine Proton Therapy Humans Radiology Nuclear Medicine and imaging Radiation treatment planning Physics Range (particle radiation) Photons Radiological and Ultrasound Technology business.industry Cumulative dose Radiotherapy Planning Computer-Assisted Radiotherapy Dosage medicine.disease 10044 Clinic for Radiation Oncology combined proton-photon therapy Female Radiotherapy Intensity-Modulated fixed proton beamline Protons Nuclear medicine business |
| Zdroj: | Physics in Medicine and Biology, 66 (23) |
| ISSN: | 1361-6560 0031-9155 |
| Popis: | Objective. Proton therapy remains a limited resource due to gantry size and its cost. Recently, a new design without a gantry has been suggested. It may enable combined proton-photon therapy (CPPT) in conventional bunkers and allow the widespread use of protons. In this work, we explore this concept for breast cancer. Methods. The treatment room consists of a LINAC for intensity modulated radiation therapy (IMRT), a fixed proton beamline (FBL) with beam scanning and a motorized couch for treatments in lying positions with accurate patient setup. Thereby, proton and photon beams are delivered in the same fraction. Treatment planning is performed by simultaneously optimizing IMRT and IMPT plans based on the cumulative dose. The concept is investigated for three breast cancers where the goal is to minimize mean dose to the heart and lung while delivering 40.05 Gy in 15 fractions to the PTV with a SIB of 48 Gy to the tumor bed. The probabilistic approach is applied to mitigate the sensitivity to range uncertainties. Results. CPPT is particularly advantageous for irradiating concave target volumes that wrap around a curved chest wall. There, protons may deliver dose to the peripheral and medial parts of the target volume including lymph nodes. Thereby, the mean dose in normal tissues is reduced compared to single-modality IMRT. However, tangential photon beams may treat parts of the target volume near the interface to the lung. To ensure target coverage for range undershoot in an IMPT plan, proton beams have to deliberately overshoot into the lung tissue-a problem that can be mitigated via the photon component which ensures plan conformity and robustness. Conclusion. CPPT using an FBL may represent a realistic approach to make protons available to more patients. In addition, CPPT may generally improve treatment quality compared to both single-modality proton and photon treatments. Physics in Medicine and Biology, 66 (23) ISSN:1361-6560 ISSN:0031-9155 |
| Databáze: | OpenAIRE |
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