Neural Correlates of Interval Timing Deficits in Schizophrenia
| Autor: | Catalin V. Buhusi, Ariel W. Snowden |
|---|---|
| Přispěvatelé: | Frontiers Research Foundation |
| Rok vydání: | 2019 |
| Předmět: |
Mini Review
neural correlates working memory 050105 experimental psychology lcsh:RC321-571 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neuroimaging cognitive dysfunction Basal ganglia medicine 0501 psychology and cognitive sciences Prefrontal cortex lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry interval timing Neural correlates of consciousness Supplementary motor area Educational Psychology business.industry Working memory 05 social sciences SMA medicine.disease attention schizophrenia Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure nervous system Neurology Schizophrenia business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Human Neuroscience Psychology Faculty Publications Frontiers in Human Neuroscience, Vol 13 (2019) |
| ISSN: | 1662-5161 |
| Popis: | Previous research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timing impairments, there is limited focus on the neural correlates of timing in SZ. The neuroimaging literature included in the current review reports hypoactivation in the dorsal-lateral prefrontal cortex (DLPFC), supplementary motor area (SMA) and the basal ganglia (BG). Timing deficits and deficits in attention and working memory (WM) in SZ are likely due to a dysfunction of dopamine (DA) and gamma-aminobutyric acid (GABA) neurotransmission in the cortico-striatal-thalamo-cortical circuits, which are highly implicated in executive functioning and motor preparation. |
| Databáze: | OpenAIRE |
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