The hypothalamo-pituitary-adrenal axis across the normal menstrual cycle and in polycystic ovary syndrome
| Autor: | Paul M. Stewart, R. Perm, D. R. London, J. G. Ratcliffe, Andrew Parton, R. Holder |
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| Rok vydání: | 1993 |
| Předmět: |
Cortisol secretion
Adult endocrine system medicine.medical_specialty Hypothalamo-Hypophyseal System Hydrocortisone Endocrinology Diabetes and Metabolism media_common.quotation_subject Pituitary-Adrenal System Biology Luteal phase Luteal Phase Anovulation Endocrinology Adrenocorticotropic Hormone Internal medicine Follicular phase medicine Humans Menstrual cycle media_common Dehydroepiandrosterone Sulfate Hyperandrogenism Dehydroepiandrosterone medicine.disease Polycystic ovary Androgen secretion Menstruation Follicular Phase Female Secretory Rate hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0300-0664 |
| Popis: | Summary OBJECTIVE We explored the hypothesis that activation of the hypothalamo-pituitary-adrenal axis is involved in the pathogenesis of hyperandrogenism in the polycystic ovary syndrome. PATIENTS Seven women with polycystic ovary syndrome (mean age 27.6 ± 1.6 (SEM) years) (hirsutism, oligo/ amenorrhoea and elevated serum testosterone and dehydroepiandrosterone sulphate) and nine normal female controls (mean age 24.6 ± 15 years) were studied. To exclude anovulation as a confounding factor, four of these normal women were studied in both the follicular and luteal phase of the menstrual cycle. DESIGN AND MEASUREMENTS Plasma ACTH and Cortisol levels were measured at 15-minute intervals between 0600 h and 1800 h. ACTH and Cortisol mean levels, pulse number and amplitude were calculated using established computer software, programmed to identify ACTH and Cortisol peaks. RESULTS With the exception of mean plasma levels of ACTH over the 12-hour period, which were reduced in the luteal phase of the menstrual cycle (1.8 ± 0.3 pmol/l) compared to the follicular phase (2.3 ± 0.2 pmol/l, P < 005), there were no differences in the pattern of ACTH or Cortisol secretion across the normal cycle. In polycystic ovary syndrome, 12-hour ACTH pulse frequency was reduced (3.6 ± 0 7) compared with controls (5.9 ± 0.6, P |
| Databáze: | OpenAIRE |
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