Thermodynamic Analysis of Allosteric and Chelate Cooperativity in Di- and Trivalent Ammonium/Crown-Ether Pseudorotaxanes
| Autor: | Nora L. Traulsen, Karol Nowosinski, Christoph A. Schalley, Larissa K. S. von Krbek |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Magnetic Resonance Spectroscopy Molecular Structure Rotaxanes Chemistry Organic Chemistry Inorganic chemistry Allosteric regulation Cooperativity Isothermal titration calorimetry Nuclear magnetic resonance spectroscopy Biochemistry Quaternary Ammonium Compounds Crystallography chemistry.chemical_compound Models Chemical Crown Ethers Molecule Humans Thermodynamics Chelation Ammonium Physical and Theoretical Chemistry Crown ether |
| Zdroj: | Organic letters. 17(20) |
| ISSN: | 1523-7052 |
| Popis: | A detailed thermodynamic analysis of the axle-wheel binding in di- and trivalent secondary ammonium/[24]crown-8 pseudorotaxanes is presented. Isothermal titration calorimetry (ITC) data and double mutant cycle analyses reveal an interesting interplay of positive as well as negative allosteric and positive chelate cooperativity thus providing profound insight into the effects governing multivalent binding in these pseudorotaxanes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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