Combination salvage chemotherapy with MIZE (ifosfamide-mesna, idarubicin and etoposide) for relapsing or refractory lymphoma
Autor: | Abel-Alzueta, Roberto Cacchione, Reinaldo Campestri, C Albera, M Nicastro, V Noviello, Dardo Riveros, R Bèguelin, M Dragosky, P Schnidrig, Guy Garay, J. Dupont, E Triguboff, Elsa Nucifora, José Tejada Fernández |
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Rok vydání: | 1997 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Salvage therapy Neutropenia Gastroenterology Refractory Recurrence Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Idarubicin Humans Ifosfamide Survival rate Etoposide Aged Mesna Salvage Therapy Chemotherapy business.industry Lymphoma Non-Hodgkin Hematology Middle Aged medicine.disease Surgery Oncology Female business medicine.drug |
Zdroj: | Leukemialymphoma. 26(5-6) |
ISSN: | 1042-8194 |
Popis: | In this study, 54 patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) were treated in a phase II, multicentric trial with ifosfamide-mesna 1500 mg/m2 IV days 1-3, idarubicin 12 mg/m2 IV day 1 and etoposide 100 mg/m2 IV day 1-3 (MIZE). Overall response was 72%; complete response (CR) and partial response (PR) were 46% and 26% respectively. In Stage I-II pts CR was 59% and in Stage III-IV pts CR was 40.5%. Patients who relapsed from an initial CR had a 64% CR rate when treated with MIZE, in contrast to refractory disease's patients who only had 19% CR (p = 0.004). The group of pts that had an objective response (CR + PR) to front line therapy had a 2 year survival rate of 55% compared with none for refractory disease (p = 0.029) after salvage therapy. Median survival for the entire group was 17.5 months. Better survival was seen in pts who were asymptomatic with low levels of LDH, previous CR, non high-grade histology, and limited disease stage at relapse. Toxicity was mainly hematologic: 91.5% had neutropenia, (56.5% grade III-IV), and 9.5% died from infectious complications. Other clinical toxicities including cardiac toxicity were negligible. MIZE chemotherapy was effective in patients with relapsed and refractory lymphoma and showed limited clinical and cardiac toxicity. Myelosupression was the most frequent single toxicity. |
Databáze: | OpenAIRE |
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