Calix[4]arene decorated with four Tn antigen glycomimetic units and P3CS immunoadjuvant: synthesis, characterization, and anticancer immunological evaluation
| Autor: | Corrada Geraci, Angelo Spadaro, Grazia M. L. Consoli, Pappalardo Ms, Eva Galante, Ennio Bousquet |
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| Rok vydání: | 2008 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Magnetic Resonance Spectroscopy Stereochemistry Antibodies Neoplasm cluster effect Lipoproteins Tn antigen Biomedical Engineering Pharmaceutical Science Bioengineering Enzyme-Linked Immunosorbent Assay Immunoadjuvant Cancer Vaccines vaccine candidates Mice Tn-antigen Antigen Adjuvants Immunologic Phenols In vivo Glycomimetic Neoplasms Moiety Animals Antigens Tumor-Associated Carbohydrate Pharmacology Mice Inbred BALB C biology Chemistry Immunogenicity Organic Chemistry Molecular Mimicry Dipeptides Immunoglobulin G biology.protein Female Indicators and Reagents molecular recognition Chromatography Thin Layer Immunotherapy Antibody Calixarenes Biotechnology |
| Zdroj: | Bioconjugate chemistry 19 (2008): 751–758. doi:10.1021/bc700411w info:cnr-pdr/source/autori:Geraci C.; Consoli G. M. L.; Galante E.; Bousquet E.; Pappalardo M.; Spadaro A./titolo:Calix[4]arene Decorated with Four Tn Antigen Glycomimetic Units and P3CS Immunoadjuvant: Synthesis, Characterization, and Anticancer Immunological Evaluation/doi:10.1021%2Fbc700411w/rivista:Bioconjugate chemistry/anno:2008/pagina_da:751/pagina_a:758/intervallo_pagine:751–758/volume:19 |
| ISSN: | 1043-1802 |
| DOI: | 10.1021/bc700411w |
| Popis: | A novel anticancer vaccine candidate built on a nonpeptidic scaffold has been synthesized. Four S-Tn tumor-associated glycomimetic antigens have been clustered onto a calix[4]arene scaffold bearing an immunoadjuvant moiety (P3CS). The immunogenicity of the synthetic construct has been investigated by immunization of mice in vivo. ELISA assay has evidenced that the tetravalent construct stimulates a higher production of anti-Tn antigen IgG antibodies when compared to an analogous monovalent compound. This result is ascribable to an antigen cluster effect and makes the reported vaccine candidate a good mimic of the natural motifs present on the mucine surface. |
| Databáze: | OpenAIRE |
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