Vascular Permeability: Regulation Pathways and Role in Kidney Diseases
| Autor: | Amélie Calmont, Christos Chatziantoniou, Anxiang Cai |
|---|---|
| Přispěvatelé: | Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Gestionnaire, HAL Sorbonne Université 5 |
| Rok vydání: | 2020 |
| Předmět: |
Vascular Endothelial Growth Factor A
030232 urology & nephrology Vascular permeability 030204 cardiovascular system & hematology Angiopoietin Capillary Permeability 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chronic kidney disease medicine Humans Endothelial dysfunction Diabetic kidney disease [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Kidney business.industry Acute kidney injury [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism medicine.disease Leukocyte extravasation 3. Good health Vascular endothelial growth factor medicine.anatomical_structure Receptors Vascular Endothelial Growth Factor chemistry Cancer research Kidney Diseases Vascular endothelial cadherin business Vascular Permeability and Kidney Diseases Vascular permeability Kidney disease Signal Transduction |
| Zdroj: | Nephron Physiology Nephron Physiology, Karger, 2021, 145 (3), pp.297-310. ⟨10.1159/000514314⟩ |
| ISSN: | 2235-3186 1660-8151 1660-2137 |
| Popis: | Background: Vascular permeability (VP) is a fundamental aspect of vascular biology. A growing number of studies have revealed that many signalling pathways govern VP in both physiological and pathophysiological conditions. Furthermore, emerging evidence identifies VP alteration as a pivotal pathogenic factor in acute kidney injury, chronic kidney disease, diabetic kidney disease, and other proteinuric diseases. Therefore, perceiving the connections between these pathways and the aetiology of kidney disease is an important task as such knowledge may trigger the development of novel therapeutic or preventive medical approaches. In this regard, the discussion summarizing VP-regulating pathways and associating them with kidney diseases is highly warranted. Summary: Major pathways of VP regulation comprise angiogenic factors including vascular endothelial growth factor/VEGFR, angiopoietin/Tie, and class 3 semaphorin/neuropilin and inflammatory factors including histamine, platelet-activating factor, and leukocyte extravasation. These pathways mainly act on vascular endothelial cadherin to modulate adherens junctions of endothelial cells (ECs), thereby augmenting VP via the paracellular pathway. Elevated VP in diverse kidney diseases involves EC apoptosis, imbalanced regulatory factors, and many other pathophysiological events, which in turn exacerbates renal structural and functional disorders. Measures improving VP effectively ameliorate the diseased kidney in terms of tissue injury, endothelial dysfunction, kidney function, and long-term prognosis. Key Messages: (1) Angiogenic factors, inflammatory factors, and adhesion molecules represent major pathways that regulate VP. (2) Vascular hyperpermeability links various pathophysiological processes and plays detrimental roles in multiple kidney diseases. |
| Databáze: | OpenAIRE |
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