A new candidate for insulinomimetic vanadium complex: synergism of oxovanadium(IV)porphyrin and sodium ascorbate
| Autor: | Yusuke Adachi, Hiroyuki Yasui, Kenji Kawabe, Jitsuya Takada, Toshifumi Inohara, Hiromu Sakurai |
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| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Sodium ascorbate medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Vanadium chemistry.chemical_element Ascorbic Acid Biochemistry Chemical synthesis Diabetes Mellitus Experimental chemistry.chemical_compound synergistic effect Biomimetic Materials In vivo Drug Discovery medicine Animals Insulin insulinomimetic Molecular Biology diabetes Organic Chemistry Drug Synergism Biological activity Porphyrin In vitro Rats vanadyl complex chemistry Molecular Medicine Vanadates sodium ascorbate Nuclear chemistry |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 14:1093-1096 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2003.12.081 |
| Popis: | Vanadyl- meso -tetrakis(1-methylpyridinium-4-yl)porphyrin, VOTMpyP with the VO(N 4 ) coordination mode, was found to have a potent insulinomimetic activity on the basis of in vitro and in vivo experiments. When the complex was given simultaneously with sodium ascorbate, the high blood glucose levels of type 1 diabetic model STZ-rats were lowered by synergistic effect, probably sustaining the vanadyl state by means of ascorbate distributed in the organs and tissues of animals. This is the first finding on not only the insulinomimetic vanadyl–porphyrin complex but also the occurrence of a synergistic effect of VOTMpyP and sodium ascorbate to lower the high blood glucose levels in diabetic animals. |
| Databáze: | OpenAIRE |
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