Antidepressant Activity of Diterpene Alkaloids of Aconitum baicalense Turcz
| Autor: | A. A. Semenov, S. V. Pushkarskiy, Yu. V. Nesterova, N. I. Suslov, T. N. Povetieva |
|---|---|
| Předmět: |
Serotonin
Aconitum Behavior Animal biology Chemistry General Medicine Pharmacology biology.organism_classification Aconitum baicalense Antidepressive Agents General Biochemistry Genetics and Molecular Biology Tail suspension test Mice chemistry.chemical_compound Alkaloids Animals Antidepressant Female heterocyclic compounds Motor activity Diterpenes Diterpene |
| Zdroj: | ResearcherID |
| Popis: | Course treatment with diterpene alkaloids of Aconitum baicalense in mice reduced the time of immobilization in the tail suspension test and produced an antiexudative effect in mouse model of serotonin-induced edema. In the open fi eld test, application of alkaloids did not change the total motor activity, orientation and exploratory behavior, and emotional reactions of animals. Experimental data suggest that diterpene alkaloids of Aconitum baicalensis exhibit antidepressant properties, possibly due to modulation of sensitivity to serotonin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|