Whole Cells as Biocatalysts in Organic Transformations
| Autor: | José Hernández-Arias, Diego Gamba-Sánchez, Liliana Becerra-Figueroa, Fabián Garzón-Posse |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
biocatalysis
Pharmaceutical Science Review Saccharomyces cerevisiae Sulfides 010402 general chemistry 01 natural sciences Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Physical and Theoretical Chemistry Enantiomeric excess enantioselective transformations Biotransformation Zymomonas 010405 organic chemistry Organic Chemistry whole cells Enantioselective synthesis Penicillium Stereoisomerism Ketones Combinatorial chemistry 0104 chemical sciences chemistry Chemistry (miscellaneous) Biocatalysis Natural processes Alcohols Molecular Medicine Organic synthesis Oxidation-Reduction |
| Zdroj: | Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules, Vol 23, Iss 6, p 1265 (2018) |
| ISSN: | 1420-3049 |
| Popis: | Currently, the power and usefulness of biocatalysis in organic synthesis is undeniable, mainly due to the very high enantiomeric excess reached using enzymes, in an attempt to emulate natural processes. However, the use of isolated enzymes has some significant drawbacks, the most important of which is cost. The use of whole cells has emerged as a useful strategy with several advantages over isolated enzymes; for this reason, modern research in this field is increasing, and various reports have been published recently. This review surveys the most recent developments in the enantioselective reduction of carbon-carbon double bonds and prochiral ketones and the oxidation of prochiral sulfides using whole cells as biocatalytic systems. |
| Databáze: | OpenAIRE |
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