Effectivity of oral recombinant DNA vaccine against Streptococcus agalactiae in Nile tilapia
| Autor: | Yi Geng, Xingli Wang, Lingyuan Huang, Xiaoli Huang, Qian Yang, Kaiyu Wang, Weimin Lai, Defang Chen, Ling Zhu, Ping Ouyang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Fish Proteins
0301 basic medicine food.ingredient Interleukin-1beta Immunology Administration Oral medicine.disease_cause Streptococcus agalactiae law.invention DNA vaccination Microbiology Fish Diseases 03 medical and health sciences Nile tilapia Blood serum Immune system food law Streptococcal Infections Vaccines DNA medicine Animals biology Superoxide Dismutase Tumor Necrosis Factor-alpha Drug Administration Routes Vaccination Tilapia Complement C3 04 agricultural and veterinary sciences biology.organism_classification Virology Immunity Innate Up-Regulation 030104 developmental biology Bacterial Vaccines 040102 fisheries Recombinant DNA 0401 agriculture forestry and fisheries Muramidase Developmental Biology |
| Zdroj: | Developmental & Comparative Immunology. 77:77-87 |
| ISSN: | 0145-305X |
| DOI: | 10.1016/j.dci.2017.07.024 |
| Popis: | The effects of oral vaccination by two immune routes (gavage and mixed fodder administration) using a recombinant DNA vaccine SL7207-pVAX1- sip against Streptococcus agalactiae were assessed. SL7207-pVAX1- sip significantly enhanced various innate immune responses of tilapia, such as total serum protein, superoxide dismutase activity, lysozyme activity, complement C3 concentration in serum, serum antibacterial activity, and interleukin 1β and tumor necrosis factor-α. Vaccinated fish had higher relative percent survival values (57% and 63% for gavage group and mix fodder administration, respectively) at 10 weeks after S. agalactiae infection. When administered mixed fodder, the DNA vaccine SL7207-pVAX1- sip against S. agalactiae may produce more effective protection. These findings can promote the application and development of DNA vaccines in aquaculture. |
| Databáze: | OpenAIRE |
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