Coexistent hairy cell leukaemia and chronic lymphocytic leukaemia

Autor:	G. Ahsan, N. G. P. Slater, Julia Phillips, S. A. Brown
Rok vydání:	1998
Předmět:	Male Cancer Research Gene Rearrangement B-Lymphocyte Heavy Chain Lymphoproliferative disorders Somatic evolution in cancer immune system diseases Interferon hemic and lymphatic diseases medicine Humans Aged Leukemia Hairy Cell business.industry Large-cell lymphoma Neoplasms Second Primary Hematology Gene rearrangement medicine.disease Immunohistochemistry Leukemia Lymphocytic Chronic B-Cell Leukemia medicine.anatomical_structure Oncology Immunology Immunoglobulin heavy chain Bone marrow business medicine.drug
Zdroj:	Leukemialymphoma. 30(1-2)
ISSN:	1042-8194
Popis:	Chronic lymphocytic leukaemia (CLL) and hairy cell leukaemia (HCL) are chronic B-cell lymphoproliferative disorders (B-LPDs) with distinct clinical, morphological and immunocytochemical features. Transformation of CLL into other B-LPDs (prolymphocytic leukaemia (PLL) and large cell lymphoma) is a well recognised phenomenon. One previous report has suggested that HCL may also arise by clonal evolution from CLL. We report the case of a 75 year old man in whom a diagnosis of coexisting HCL was made seventeen years after an initial diagnosis of CLL. Immunoglobulin heavy chain rearrangement studies suggest that the two B-LPDs developed independently. A steady increase in the bone marrow HCL component at the expense of the CLL component was observed with time, suggesting that HCL may have a growth advantage over CLL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b0d66f7d7a729163bc83dde945430f https://pubmed.ncbi.nlm.nih.gov/9669692 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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