A deadly prescription: combination of methotrexate and trimethoprim-sulfamethoxazole
| Autor: | Bilal Lashari, Usman Sarwar, Mohsin Hamid, Joseph Crocetti, Irfan Ahsan, Ida Micaily |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
lcsh:Internal medicine medicine.medical_specialty Chronic bronchitis Pneumocystis pneumonia Gastroenterology trimethoprim-sulfamethoxazole pancytopenia deadly drug interaction folinic acid rescue 03 medical and health sciences 0302 clinical medicine immune system diseases Psoriasis Internal medicine Internal Medicine medicine 030212 general & internal medicine lcsh:RC31-1245 skin and connective tissue diseases 030203 arthritis & rheumatology Leukopenia business.industry Sulfamethoxazole medicine.disease Trimethoprim Methotrexate Rheumatoid arthritis medicine.symptom business medicine.drug |
| Zdroj: | Journal of Community Hospital Internal Medicine Perspectives, Vol 8, Iss 3, Pp 149-151 (2018) |
| ISSN: | 2000-9666 |
| Popis: | Methotrexate (MTX) is a chemotherapeutic synthetic(s) phase cell cycle inhibitor, and its role has evolved as an immunological agent in autoimmune diseases like rheumatoid arthritis, psoriasis, and systemic lupus erythematosus, etc. Trimethoprim-sulfamethoxazole (TS) is one of the most widely prescribed antibiotics commonly used for urinary tract infections, exacerbations of chronic bronchitis, traveler’s diarrhea, and pneumocystis pneumonia. Both MTX and TS can have significantly overlapping side effects involving dermatologic, renal, and hematological systems, and the combination of these can be deadly. Our case is about the combination of MTX and TS that leads to mucocutaneous ulceration, leukopenia, and renal insufficiency. The purpose of this case is to increase awareness of potentially significant toxicity from the combination of MTX with TS. Abbreviations: MTX: methotrexate; TS: trimethoprim-sulfamethoxazole; ED: emergency department; IV: intravenous; GI: gastrointestinal; NSAIDs: nonsteroidal anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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