Comparative evaluation of propofol and thiopentone for total intravenous anaesthesia
| Autor: | Hillel I. Kashtan, Deena Kapala, Gerald Edelist, Joseph S. Mallon |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Consciousness medicine.medical_treatment Diastole Anesthesia General Comparative evaluation Random Allocation Anesthesiology Heart rate medicine Humans Single-Blind Method Postoperative Period Thiopental Propofol Chi-Square Distribution business.industry Tracheal intubation General Medicine Anesthesiology and Pain Medicine Anesthesia Anesthesia Recovery Period Anesthesia Intravenous Female Total intravenous anaesthesia business Psychomotor Performance medicine.drug |
| Zdroj: | Canadian journal of anaesthesia = Journal canadien d'anesthesie. 37(2) |
| ISSN: | 0832-610X |
| Popis: | Sixty unpremedicated ASA physical status I or II patients scheduled for surgical procedures of intermediate duration (15 to 60 min) were studied to evaluate the safety and efficacy of propofol, to measure recovery times and to compare the return of psychomotor and cognitive function with thiopentone. Patients were randomly allocated into two groups. Anaesthesia was induced and maintained by either propofol (2.0- 2.5 mg· kg- 1 followed by a continuous infusion 0.1- 0.2 mg· kg- 1 · min- 1) or thiopentone (4.0- 5.0 mg · kg- 1, and infusion rate 0.16- 0.32 mg · kg- 1 min- 1), titrated to patient response. Succinylcholine was administered to facilitate tracheal intubation and maintain neuromuscular blockade. Induction of anaesthesia was slightly longer with propofol than thiopentone (42.2 vs 29.8 sec) and was smooth with both drugs. Postintubation increases in heart rate, and systolic and diastolic blood pressures were attenuated by propofol when compared with thiopentone. After the administration of propofol, times to eye opening (6.4 ± 4.3 vs 13.9 ± 15.9 min), response to verbal command(7.6 ± 6.3 vs 15.4 ± 16.6 min) and orientation (22.7 ± 12.8 vs 36.2 ± 23.1 min), were significantly shorter. Psychomotor and cognitive function returned earlier with propofol and fewer side effects were noted. At 24 hr there was no distinguishable difference between groups. Propofol is a safe anaesthetic agent with the potential for early patient discharge and street fitness after outpatient procedures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink