Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report
| Autor: | Gilles Chopard, M. Bereau, Magali Nicolier, Sabrina Ferreira, Emmanuel Haffen, Hatem Bouladour, Julie Monnin, Elfried Dariel, Pierre Vandel, Louis Berthet, Eloi Magnin, Geraldine Sylvestre |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Audiology Neuropsychological Tests behavioral disciplines and activities 050105 experimental psychology Primary progressive aphasia 03 medical and health sciences 0302 clinical medicine Cognition Aphasia medicine Humans 0501 psychology and cognitive sciences Aged Mini–Mental State Examination medicine.diagnostic_test 05 social sciences Neuropsychology medicine.disease Transcranial Magnetic Stimulation Paraphasia Transcranial magnetic stimulation Aphasia Primary Progressive Treatment Outcome nervous system Neurology Female Neurology (clinical) Verbal memory medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | European neurology. 76(1-2) |
| ISSN: | 1421-9913 |
| Popis: | Background/Aims: High frequency repetitive transcranial magnetic stimulation (hf-rTMS) improves language skills in Alzheimer's disease (AD). We report the use of hf-rTMS in a patient with logopenic primary progressive aphasia (LPPA) due to AD. Method: hf-rTMS was applied to the left dorsolateral prefrontal cortex of a LPPA patient. Cerebral perfusion, neuropsychological and linguistic performances were evaluated before and 1 month after hf-rTMS. Results: The tolerance was good. Improvements on linguistic (fluency, naming, lesser paraphasia) and cognitive skills (Mini Mental State Examination, verbal memory free recall, speed processing) and cerebral perfusion were observed. Conclusion: hf-rTMS can be used in LPPA patients. A procognitive effect persisting several weeks after stimulation in LPPA patients was suggested and should therefore be evaluated in a clinical trial as an adjunctive therapeutic tool. |
| Databáze: | OpenAIRE |
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