Canine echinococcosis: genetic diversity of Echinococcus granulosus sensu stricto (s.s.) from definitive hosts
| Autor: | María Magdalena Munguía Reyes, David Jenkins, F M Elmestiri, A Al-Hindi, Philip S. Craig, Imad Buishi, Paul R. Torgerson, A A Eljaki, Andrew M. Griffiths, Wai San Lett, S Pointing, S Lahmar, M A Alrefadi, S A Engliez, Munehiro Okamoto, Belgees Boufana |
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| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Veterinary medicine Genotype purl.org/pe-repo/ocde/ford#3.03.07 [https] Population 2405 Parasitology Zoology 610 Medicine & health purl.org/pe-repo/ocde/ford#4.02.00 [https] Biology Echinococcosis/parasitology/veterinary Electron Transport Complex IV Dogs Helminth Proteins/genetics Echinococcosis Electron Transport Complex IV/genetics Sheep/parasitology Genetic variation parasitic diseases medicine Humans Animals Dog Diseases 10599 Chair in Veterinary Epidemiology Echinococcus granulosus education Phylogeny education.field_of_study Genetic diversity Sheep Haplotype Genetic Variation Echinococcus granulosus/classification/genetics/isolation & purification Helminth Proteins General Medicine biology.organism_classification medicine.disease Metacestode Haplotypes Dog Diseases/parasitology 570 Life sciences biology Female Animal Science and Zoology Parasitology 1103 Animal Science and Zoology |
| Popis: | Canids, particularly dogs, constitute the major source of cystic echinococcosis (CE) infection to humans, with the majority of cases being caused byEchinococcus granulosus(G1 genotype). Canine echinococcosis is an asymptomatic disease caused by adult tapeworms ofE. granulosussensu lato (s.l.). Information on the population structure and genetic variation of adultE. granulosusis limited. Using sequenced data of the mitochondrial cytochromecoxidase subunit 1 (cox1) we examined the genetic diversity and population structure of adult tapeworms ofE. granulosus(G1 genotype) from canid definitive hosts originating from various geographical regions and compared it to that reported for the larval metacestode stage from sheep and human hosts.Echinococcus granulosus(s.s) was identified from adult tapeworm isolates from Kenya, Libya, Tunisia, Australia, China, Kazakhstan, United Kingdom and Peru, including the first known molecular confirmation from Gaza and the Falkland Islands. Haplotype analysis showed a star-shaped network with a centrally positioned common haplotype previously described for the metacestode stage from sheep and humans, and the neutrality indices indicated population expansion. Low Fst values suggested that populations of adultE. granulosuswere not genetically differentiated. Haplotype and nucleotide diversities forE. granulosusisolates from sheep and human origin were twice as high as those reported from canid hosts. This may be related to self-fertilization ofE. granulosusand/or to the longevity of the parasite in the respective intermediate and definitive hosts. Improved nuclear single loci are required to investigate the discrepancies in genetic variation seen in this study. |
| Databáze: | OpenAIRE |
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