Vagal sensory neurons drive mucous cell metaplasia

Autor:	Benjamin Doyle, Clifford J. Woolf, Bruce P. Bean, Junwei Huang, David Roberson, Bruce D. Levy, Maryam Ahmadi, Simmie L. Foster, Sébastien Talbot, Liam E Browne, Jo-Chiao Wang, Ajay S. Yekkirala
Rok vydání:	2020
Předmět:	Male 0301 basic medicine Pathology medicine.medical_specialty Sensory Receptor Cells Immunology TRPV1 Substance P Sensory system Optogenetics digestive system Article Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Metaplasia Animals Immunology and Allergy Medicine Gene silencing Lung Inflammation business.industry Vagus Nerve respiratory system Immunity Innate respiratory tract diseases 3. Good health Mice Inbred C57BL Mucus 030104 developmental biology medicine.anatomical_structure nervous system chemistry Female medicine.symptom business Airway 030217 neurology & neurosurgery
Zdroj:	J Allergy Clin Immunol
ISSN:	0091-6749
DOI:	10.1016/j.jaci.2020.01.003
Popis:	summary Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ac01b1fdef7c9fdffe978fad021d16 https://doi.org/10.1016/j.jaci.2020.01.003 Zobrazit plný text záznamu Full Text from ScienceDirect