Sarcoidosis of the Liver and Bile Ducts
| Autor: | Kamal G. Ishak |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty Granulomatous cholangitis Sarcoidosis business.industry Liver Diseases Bile Duct Diseases General Medicine medicine.disease Gastroenterology Primary sclerosing cholangitis Asteroid body Primary biliary cirrhosis Ductopenia Giant cell hemic and lymphatic diseases Internal medicine medicine Humans Portal hypertension business |
| Zdroj: | Mayo Clinic Proceedings. 73:467-472 |
| ISSN: | 0025-6196 |
| DOI: | 10.1016/s0025-6196(11)63733-6 |
| Popis: | In sarcoidosis, granulomas are frequently present in multiple organs, including the liver. Typically, epithelioid granulomas (noncaseating) are scattered throughout the liver, but confluent granulomas can be present in cases with severe hepatic involvement. The characteristic inclusions in giant cells (for example, Schaumann bodies and asteroid bodies) are not seen in all cases and are not pathognomonic. The granulomas of sarcoidosis may heal without a trace, but confluent granulomas can result in extensive, irregular scarring. Occlusion of intrahepatic portal vein branches by the granulomatous inflammation probably accounts for the development of portal hypertension in some cases. A granulomatous cholangitis leading to ductopenia seems to be the underlying pathogenetic mechanism of the chronic cholestatic syndrome of sarcoidosis. Recognition of this syndrome is important in the differential diagnosis of other chronic cholestatic diseases, such as primary biliary cirrhosis or primary sclerosing cholangitis. Other rare complications of sarcoidosis are the Budd-Chiari syndrome and obstructive jaundice attributable to hepatic hilar lymphadenopathy or strictures of the bile ducts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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