The mast cell stabilizing activity of Chaga mushroom critical for its therapeutic effect on food allergy is derived from inotodiol
| Autor: | Thi Minh Nguyen Nguyet, Ji Sun Lee, Young Ho Kim, Maria Lomunova, Seol Kyu Park, Jong Seong Kang, Ba Vinh Le, Inkyu Hwang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Allergy Ovalbumin medicine.drug_class Immunology Immunoglobulin E Microbiology Lanosterol Mice 03 medical and health sciences chemistry.chemical_compound Th2 Cells 0302 clinical medicine Food allergy Anti-Allergic Agents medicine Animals Humans Immunology and Allergy Mast Cells Mast cell stabilizer Pharmacology Inotodiol Methylene Chloride Mice Inbred BALB C Ethanol biology Basidiomycota Mast cell medicine.disease biology.organism_classification Disease Models Animal 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis biology.protein Th17 Cells Inonotus obliquus Female Food Hypersensitivity |
| Zdroj: | International Immunopharmacology. 54:286-295 |
| ISSN: | 1567-5769 |
| Popis: | While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known. We examined the effect of 70% ethanol extract of Chaga mushroom (EE) and its dichloromethane (DF) and aqueous (AF) fractions using a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and found that only EE and DF ameliorated allergy symptoms to a significant extent. The in vivo mast cell-stabilizing activity was also found only in EE and DF whereas the activities to suppress Th2 and Th17 immune responses and cOVA-specific IgE production in the small intestine were observed in all three treatment regimens, implying that inhibition of the mast cell function by lipophilic compounds was vital for the therapeutic effect. Results also indicated that inotodiol, a triterpenoid predominantly present in DF, played an active role as a mast cell stabilizer. |
| Databáze: | OpenAIRE |
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