Prevalence and predictors of proton pump inhibitor partial response in gastroesophageal reflux disease in systemic sclerosis: a prospective study

Autor: Ratanavadee Nanagara, Pisaln Mairiang, Kitti Chunlertrith, Siraphop Suwannaroj, Suwassa Namvijit, Chingching Foocharoen, Orathai Wantha, Ajanee Mahakkanukrauh
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Visual Analog Scale
lcsh:Medicine
Gastroenterology
0302 clinical medicine
Esophageal dysphagia
Prevalence
Prospective Studies
Prospective cohort study
skin and connective tissue diseases
lcsh:Science
Omeprazole
Aged
80 and over
Multidisciplinary
integumentary system
Middle Aged
Dysphagia
humanities
Treatment Outcome
Gastroesophageal Reflux
Systemic sclerosis
Female
030211 gastroenterology & hepatology
medicine.symptom
medicine.drug
Adult
medicine.medical_specialty
Visual analogue scale
medicine.drug_class
Proton-pump inhibitor
Risk Assessment
Article
Drug Administration Schedule
03 medical and health sciences
Gastro-oesophageal reflux disease
Internal medicine
medicine
Humans
Aged
030203 arthritis & rheumatology
Scleroderma
Systemic
business.industry
lcsh:R
Reflux
Proton Pump Inhibitors
medicine.disease
digestive system diseases
GERD
lcsh:Q
business
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
ISSN: 2045-2322
Popis: Proton pump inhibitor (PPI) twice daily dosing is a standard therapy for gastroesophageal reflux disease (GERD) in systemic sclerosis (SSc) but there is no data on its response rate or the predictors of PPI-partial response GERD. Aims were to determine the prevalence of PPI-partial response GERD in SSc and to define its predictors. A prospective study was conducted in SSc patients with GERD. The patients were treated with omeprazole 20 mg bid for 4 weeks. The severity of symptom-grading by visual analogue scale (VAS) and frequency of symptoms by frequency scale for symptoms of GERD (FSSG) were assessed at baseline and 4 weeks after treatment. PPI-partial response GERD was defined as less than 50% improvement in the VAS for severity of symptom as well as acid reflux score by FSSG after treatment. According to the sample size calculation, 243 SSc-GERD patients were enrolled; of whom 166 (68.3%) had the diffuse cutaneous SSc. PPI-partial response GERD was found in 131 SSc patients (prevalence 53.9%; 95%CI 47.4–60.3). The multivariate analysis revealed that esophageal dysphagia was an only predictor the PPI-partial response GERD (OR 1.82; 95%CI 1.01–3.29) while neither SSc subset nor severity of skin tightness were significantly associated with PPI-partial response GERD. Half of the SSc patients were PPI-partial response GERD. Esophageal dysphagia was the only predictor of PPI-partial response GERD in SSc patients. Screening for dysphagia before starting GERD treatment is helpful for assessment the risk of PPI refractoriness GERD in SSc patients.
Databáze: OpenAIRE
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