A case of neuromyelitis optica presenting marked pleocytosis and hypoglycorrhachia
| Autor: | Kazuki Yokokawa, Hirohiko Shizukawa, Shun Shimohama, Mai Fujikura |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
030110 physiology 0301 basic medicine CSF glucose Leukocytosis Antiviral Agents 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid medicine Humans Pleocytosis Autoantibodies Aquaporin 4 Paraplegia Neuromyelitis optica business.industry Neuromyelitis Optica Optic Nerve Middle Aged medicine.disease Magnetic Resonance Imaging Hyperintensity Anti-Bacterial Agents Glucose Spinal Cord Anesthesia Sensation Disorders Hypoglycorrhachia Vomiting Drug Therapy Combination Neurology (clinical) medicine.symptom business Biomarkers Immunosuppressive Agents 030217 neurology & neurosurgery |
| Zdroj: | Rinsho Shinkeigaku. 56:569-572 |
| ISSN: | 1882-0654 0009-918X |
| DOI: | 10.5692/clinicalneurol.cn-000753 |
| Popis: | A 57-year-old man initially developed chest discomfort, nausea, vomiting, headache and low-grade fever, followed by paraplegia, sensory disturbance below level Th5 and bilateral visual loss. He was admitted to our hospital on the 15th day of illness. MRI short T1 inversion recovery image showed multiple longitudinal lesions in the spinal cord below C3, and T2-weighted image showed abnormal hyperintensity within the left optic nerve. Cerebrospinal fluid (CSF) analysis revealed marked pleocytosis (1,719/μl) and hypoglycorrhachia (CSF glucose; 20 mg/dl). Intensive immunosuppressive therapy combined with antibiotics and antiviral agent were started immediately, resulting in relatively good visual outcome but no improvement of paraplegia and sensory disturbance. The patient's serum sample on admission was subsequently reported to be positive for anti-aquaporin-4 antibody. With no evidence of infectious diseases, neuromyelitis optica (NMO) was diagnosed. It should be borne in mind that marked hypogylcorrhachia may also be seen in NMO. |
| Databáze: | OpenAIRE |
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