The association of lipoprotein(a) and apolipoprotein(a) phenotypes with peripheral artery disease
| Autor: | S.N. Pokrovsky, E.A. Klesareva, N.A. Tmoyan, Olga I. Afanasieva, Marat V. Ezhov, Kukharchuk Vv, O. A. Razova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
History medicine.medical_specialty Apolipoprotein B Endocrinology Diabetes and Metabolism Immunoblotting lcsh:Medicine Coronary Disease 030204 cardiovascular system & hematology peripheral artery disease Apoprotein(a) Risk Assessment Gastroenterology Peripheral Arterial Disease 03 medical and health sciences 0302 clinical medicine lipoprotein(a) Risk Factors Internal medicine Diabetes mellitus Humans Medicine cardiovascular diseases Myocardial infarction Risk factor Correlation of Data Aged biology business.industry apolipoprotein(a) phenotypes Immunochemistry lcsh:R General Medicine Lipoprotein(a) Odds ratio Middle Aged Atherosclerosis medicine.disease Obesity Phenotype atherosclerosis of lower limbs arteries biology.protein Female Family Practice business 030217 neurology & neurosurgery Lipoprotein |
| Zdroj: | Терапевтический архив, Vol 90, Iss 9, Pp 31-36 (2018) |
| ISSN: | 2309-5342 0040-3660 |
| DOI: | 10.26442/terarkh201890931-36 |
| Popis: | Aim. Lipoprotein(a) [Lp(a)] is an independent risk factor of coronary heart disease (CHD) and myocardial infarction. Data about the role of Lp(a) in the development of peripheral artery disease (PAD) is controversial and uncertain. The aim of the study was to evaluate the association between Lp(a), apolipoprotein(a) [apo(a)] phenotypes and PAD. Materials and methods. The study included 998 patients (707 male and 291 female, average age 60±12). The patients were divided into 4 groups depending on the presence or absence PAD and CHD: group I (n=188, PAD+CHD+), group II (n=78, PAD+CHD-), group III (n=407, PAD-CHD+), group IV (n=325, PAD-CHD-). Results. The level of Lp(a) was significantly higher in groups I, II, III in comparison with patients of control group (group IV): 34 [15; 80], 30 [10; 49], 22 [8; 60] mg/dl vs. 15 [6; 35] mg/dl respectively, p |
| Databáze: | OpenAIRE |
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