Synthesis, nucleic acid binding and cytotoxicity of polyethyleneimine-copper(II) complexes containing 1,10-phenanthroline and l-valine
| Autor: | Thyagarajan Thirunalasundari, Sankaralingam Arunachalam, Jagadeesan Lakshmipraba, Devadas Avinash Gandi |
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| Rok vydání: | 2010 |
| Předmět: |
Stereochemistry
Cell Survival Phenanthroline Antineoplastic Agents Saccharomyces cerevisiae Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship RNA Transfer Coordination Complexes Cell Line Tumor Drug Discovery Molecule Animals Humans Polyethyleneimine Binding site Pharmacology Binding Sites Molecular Structure Chemistry Hydrogen bond Organic Chemistry RNA Hydrogen Bonding Valine General Medicine DNA Nucleic acid Leukocytes Mononuclear Cattle Copper Phenanthrolines |
| Zdroj: | European journal of medicinal chemistry. 46(7) |
| ISSN: | 1768-3254 |
| Popis: | The polymer-copper(II) complex samples, [Cu(phen)(l-Val) BPEI]Cl·H(2)O, with varying degrees of coordination in the polymer chain, were prepared and characterized by elemental analysis and spectroscopic methods. The binding of these complex samples with both DNA and RNA has been investigated. The experimental results indicate that the polyethyleneimine-copper(II) complex samples bind with DNA and RNA mostly through surface binding; but hydrogen bonding and van der Waals interactions are also present. Evaluation of cytotoxic activity of a sample of polymer-copper(II) complex with higher degree of coordination against different cancer cell lines proved that the complex exhibited cytotoxic specificity and significant cancer cell inhibition rate. |
| Databáze: | OpenAIRE |
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