Predicting intracerebral hemorrhage by baseline magnetic resonance imaging in stroke patients undergoing systemic thrombolysis

Autor:	Dominik Michalski, Dominik Fritzsch, Karl-Titus Hoffmann, Carsten Hobohm, Sarah Budig, Joseph Classen
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Male medicine.medical_specialty thrombolysis Time Factors medicine.medical_treatment diffusion-weighted imaging Fluid-attenuated inversion recovery Tissue plasminogen activator fluid-attenuated inversion recovery Lesion Fibrinolytic Agents medicine ischemic stroke magnetic resonance imaging Humans Thrombolytic Therapy cardiovascular diseases Stroke Aged Cerebral Hemorrhage Intracerebral hemorrhage medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Thrombolysis Original Articles Middle Aged medicine.disease intracerebral hemorrhage Diffusion Magnetic Resonance Imaging Neurology Tissue Plasminogen Activator Female Neurology (clinical) Radiology medicine.symptom business Fibrinolytic agent medicine.drug
Zdroj:	Acta Neurologica Scandinavica
ISSN:	1600-0404 0001-6314
Popis:	Objectives Intracerebral hemorrhage (ICH) remains a serious complication in ischemic stroke patients undergoing systemic thrombolysis. Here, we examined whether the risk of treatment-associated hemorrhage can be predicted from magnetic resonance imaging (MRI) using fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging (DWI) within 3 h after symptom onset. Methods In this single-center observational study involving 122 ischemic stroke patients between January 2005 and December 2008, the incidence of FLAIR-positive lesions within diffusion-restricted areas was determined on baseline MRI, which was carried out prior to treatment with tissue plasminogen activator (Actilyse®) within 3 h from symptom onset. The rate of ICH was assessed by computed tomography performed within 24 h after treatment. Relationships between FLAIR-positive lesions, DWI lesion size, proportion of FLAIR/DWI-positive lesions, and occurrence of bleeding were explored. Results Data from 97 patients were evaluated. FLAIR-positive lesions were present in 25 patients (25.8%) and ICH occurred in 32 patients (33.0%). FLAIR-positive lesions were associated with a bleeding rate of 80.0% compared with 16.7% in FLAIR-negative patients (P
Databáze:	OpenAIRE
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