Association of the dopamine D2 receptor rs1800497 polymorphism with food addiction, food reinforcement, and eating behavior in Chilean adults
| Autor: | María De Los Ángeles García-Robles, Macarena Valladares, Ana María Obregón, Karina Oyarce, Paulina Pettinelli, Gary S. Goldfield |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 050103 clinical psychology TaqI 030309 nutrition & dietetics Food addiction Overweight 03 medical and health sciences chemistry.chemical_compound Surveys and Questionnaires Medicine Humans 0501 psychology and cognitive sciences Chile Reinforcement Yale Food Addiction Scale 0303 health sciences Polymorphism Genetic business.industry Receptors Dopamine D2 digestive oral and skin physiology 05 social sciences Feeding Behavior Emotional eating Anthropometry medicine.disease Obesity Behavior Addictive Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies chemistry Female Food Addiction medicine.symptom business Clinical psychology |
| Zdroj: | Eating and weight disorders : EWD. 27(1) |
| ISSN: | 1590-1262 |
| Popis: | The regulation of food intake and body weight involves two interacting systems: (a) The homeostatic system (including biological regulators of hunger and satiety) and (b) the non-homeostatic system, (involving concepts of food reinforcement and food addiction). Studies have established a strong genetic component in eating behavior and obesity. The TaqI A1 polymorphism (rs1800497) has previously been associated with eating behavior, diminished dopamine D2 receptor (DRD2) density, higher body mass, and food reinforcement, but relations to food addiction remain unclear. To evaluate the association between the polymorphism rs1800497 with eating behavior, food reinforcement and food addiction in Chilean adults. This cross-sectional study recruited a convenience sample of 97 obese, 25 overweight and 99 normal-weight adults (18–35 years). Anthropometric measurements were performed by standard procedures. Eating behavior was assessed using the: Yale Food Addiction Scale (YFAS), the Three Factor Eating Behavior Questionnaire and the Food Reinforcement Value Questionnaire (FRVQ). The DRD2 genotype (rs1800497) was determined by taqman assays. Twenty-two percentage of the participants met the criteria for food addiction. Food addiction was higher in women than men (26% vs 10.7%) and in obese compared to non-obese (40% vs 6%). There was no relationship between food addiction and DRD2 genotype. However when stratified by sex and nutritional status, obese female carriers of the A1 allele reported greater scores on emotional eating and snack food reinforcement compared to non-carriers. The DRD2 polymorphism is associated with some hedonic aspects of eating behavior, namely food reinforcement and emotional eating but not food addiction, and this association may be moderated by sex and obesity status, with obese women who are carriers of this genetic variant at higher risk. Level V: evidence obtained from a cross-sectional descriptive study. |
| Databáze: | OpenAIRE |
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