A novel replicated association between FXYD6 gene and schizophrenia
| Autor: | Wanhu Kang, Robert K. Valenzuela, Chuan Qiu, Rui Zhang, Nannan Zhong, Shemin Lu, Jie Ma, Han Yan, Huan Zhang, Tingwei Guo |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Linkage disequilibrium Adolescent Biophysics Single-nucleotide polymorphism Locus (genetics) Genome-wide association study Biology Polymorphism Single Nucleotide Biochemistry Ion Channels Linkage Disequilibrium Young Adult Asian People Chromosome regions Humans Genetic Predisposition to Disease Molecular Biology Gene Genetic association Genetics Chromosomes Human Pair 11 Haplotype Cell Biology Schizophrenia Female Genome-Wide Association Study |
| Zdroj: | Biochemical and Biophysical Research Communications. 405:118-121 |
| ISSN: | 0006-291X 1154-4201 |
| DOI: | 10.1016/j.bbrc.2011.01.005 |
| Popis: | FXYD6 gene is located in chromosome region 11q22-q24 where previous studies have shown an association with schizophrenia. However, the subsequent studies failed to replicate this finding. To investigate the relationship between FXYD6 locus and schizophrenia in Chinese population, we genotyped six single-nucleotide polymorphisms (SNPs) in this region of FXYD6 in 1142 Han Chinese subjects (576 cases and 566 controls), and performed an association analysis. Significant associations with schizophrenia and the marker rs11544201 (P=0.0028) and the haplotype rs10790212-rs11544201 (global P=0.005) were found. Our results support that FXYD6 is a susceptibility gene of schizophrenia. Replication of larger samples and functional analysis of FXYD6 are needed. |
| Databáze: | OpenAIRE |
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