Streptomyces tsukubensis VKM Aс-2618D—an Effective Producer of Tacrolimus

Autor:	V. Yu. Poshekhontseva, V. V. Fokina, S. V. Tarlachkov, A. V. Machulin, A. A. Shutov, M. V. Donova
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	surgical procedures operative Producers Biology Selection and Genetic Engineering chemical and pharmacologic phenomena Streptomyces tsukubensis biosynthesis tacrolimus FK-506 Applied Microbiology and Biotechnology Biochemistry genome dissociant
Zdroj:	Applied Biochemistry and Microbiology
ISSN:	1608-3024 0003-6838
Popis:	The Streptomyces sp. VKM Ac-2618D strain has been identified, and its morphological and physiological features have been studied in relation to the production of the immunosuppressant tacrolimus. The phenotypic variability of the strain was analyzed, and a dissociant with a high level of tacrolimus production was selected. Based on a comprehensive study of morphological, physiological, and chemotaxonomic properties and on phylogenetic analysis, the strain was named Streptomyces tsukubensis VKM Ac-2618D. The strain genome contains the full version of the tacrolimus biosynthetic gene cluster. The advantages of fed-batch cultivation mode for tacrolimus biosynthesis are shown. The results broaden the understanding of the characteristics of polyketide biosynthesis and can be used in the development of technology for tacrolimus production.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a3bebdf935ab9869e89aa339ad14a1 http://europepmc.org/articles/PMC8670718 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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