Islet antibodies associated with pancreatic B-cell dysfunction at and 3�years after diagnosis of diabetes in subjects aged 35?64�years old: degree of impairment less severe than in those aged 0?34�years old
| Autor: | G Stenstrom, Göran Sundkvist, Henrik Borg, Per Fernlund, Bo Berger |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Population Gastroenterology Islets of Langerhans chemistry.chemical_compound Endocrinology Interquartile range Insulin-Secreting Cells Diabetes mellitus Internal medicine Diabetes Mellitus Internal Medicine medicine Humans Child education B cell Autoantibodies geography education.field_of_study geography.geographical_feature_category C-Peptide biology C-peptide business.industry Infant Newborn Infant Middle Aged medicine.disease Islet Cell function medicine.anatomical_structure chemistry Child Preschool biology.protein Antibody business |
| Zdroj: | Diabetic Medicine. 23:1180-1185 |
| ISSN: | 1464-5491 0742-3071 |
| Popis: | Aims To determine differences in pancreatic B-cell function in relation to islet antibodies at diagnosis of diabetes and 3 years later in subjects aged 35–64 years old compared with those aged 0–34 years. Methods From a population-based diabetes register, 46 (0–34 years old) and 323 (35–64 years old) incident diabetic patients were investigated at diagnosis and 3 years later. Islet cell antibodies (ICA, GADA and IA-2A) and fasting plasma C-peptide were measured. Results Islet antibodies were found in 80% of the subjects aged 0–34 years and in 11% of those aged 35–64 years at diagnosis. ICA and GADA was the only combination of two islet antibodies detected in those aged 35–64 years and was, with or without IA-2A, associated with significantly lower median fasting C-peptide values than in those without or with only one antibody [0.35 nmol/l, interquartile range (IQR) 0.63 vs. 0.85 nmol/l, IQR 0.49; P = 0.0004]. However, fasting C-peptide in subjects aged 35–64 years old with multiple islet antibodies was higher than in those aged 0–34 years with islet antibodies (median 0 nmol/l, IQR 0.16, P = 0.0019). After 3 years’ follow-up, fasting C-peptide was even lower in subjects aged 35–64 years old with three islet antibodies (median 0.14 nmol/l, IQR 0.27; P = 0.05). Conclusions Islet antibodies were common in adults at diagnosis of diabetes. The combination of ICA and GADA indicates impaired B-cell function at diagnosis of diabetes in those aged 35–64 years old. |
| Databáze: | OpenAIRE |
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