Synthesis and anticancer and cytotoxic effects of novel 1,4-phenylene-bis-N-thiocarbamoylpyrazole and 1,4-phenylene-bis-pyrazolylthiazole derivatives
| Autor: | Yakup Budak, Ayşe Şahin Yağlioğlu, Meliha Burcu Gürdere, Erdoğan Kamo, Mustafa Ceylan |
|---|---|
| Přispěvatelé: | Gaziosmanpaşa Üniversitesi, 0-Belirlenecek |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Chemistry Mühendislik Positive control General Chemistry 010402 general chemistry Cell selectivity biology.organism_classification medicine.disease 01 natural sciences Mühendislik Kimya 0104 chemical sciences C6 cells HeLa Engineering Biochemistry Phenylene Carcinoma medicine Cytotoxic T cell Bis-chalcone bis-N-thiocarbamoylpyrazole bis-pyrazolylthiazole HeLa C6 anticancer activity cytotoxicity Cytotoxicity |
| Zdroj: | Volume: 41, Issue: 2 179-189 Turkish Journal of Chemistry |
| ISSN: | 1300-0527 1303-6130 |
| Popis: | Thiazolylpyrazoline derivatives were recently reported as potent anticancer agents. In this study, novel 1,4-phenylene-bis-N-thiocarbamoylpyrazoles (3a-h and 1,4-phenylene-bis-pyrazolylthiazoles (5a-h were prepared and screened for their anticancer activities against C6 (rat brain tumor cells) and HeLa (human uterus carcinoma). Anticancer activity studies were performed as a dose-dependent assay starting with eight concentrations. 5-Fluorouracil (5-FU) was used as a positive control. Compounds 3c, 3d, and 3h were examined and they revealed almost the same activities compared with 5-FU in terms of cell selectivity against C6 cells. Moreover, compounds 3a-h had lower cytotoxicity than 5-FU. The low cytotoxicity values of 3a-h as well as their high antiproliferative activity were encouraging, but further studies are required on the use of these molecules as anticancer drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|