The role of neuronal nicotinic acetylcholine receptors in antinociception: Effects of ABT-594
| Autor: | Mark W. Holladay, Michael Williams, Theresa A. Kuntzweiler, Pamela S. Puttfarcken, Diana L. Donnelly-Roberts, Clark A. Briggs, Anthony W. Bannon, Peter Curzon, Stephen P. Arneric, Michael W. Decker, Arthur L. Nikkel, R. Scott Bitner |
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| Rok vydání: | 1998 |
| Předmět: |
Neurons
Nucleus raphe magnus Pyridines Chemistry General Neuroscience Pain Analgesics Non-Narcotic Receptors Nicotinic Pharmacology Serotonergic Rats Disease Models Animal Nicotinic acetylcholine receptor Nicotinic agonist Nociception hemic and lymphatic diseases Physiology (medical) Animals Azetidines Raphe Nuclei Nicotinic Agonists Serotonin Receptor Acetylcholine receptor |
| Zdroj: | Journal of Physiology-Paris. 92:221-224 |
| ISSN: | 0928-4257 |
| DOI: | 10.1016/s0928-4257(98)80014-4 |
| Popis: | ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594. |
| Databáze: | OpenAIRE |
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