Circadian Rhythms in Bacterial Sepsis Pathology: What We Know and What We Should Know
| Autor: | Mul Fedele, Malena Lis, Senna, Camila Agustina, Aiello, Ignacio, Golombek, Diego A., Paladino, Natalia |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
SEPSIS Mini Review Immunology Immunity SISTEMA INMUNOLOGICO Microbiology QR1-502 infection Circadian Rhythm sepsis immune system Cellular and Infection Microbiology Infectious Diseases Liver circadian rhythms HIPOTERMIA Animals Humans Myeloid Cells RITMO CIRCADIANO INFECCIONES hypothermia |
| Zdroj: | Frontiers in Cellular and Infection Microbiology Frontiers in cellular and infection microbiology. 2021, 11 Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) Repositorio Institucional (UCA) Pontificia Universidad Católica Argentina instacron:UCA |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2021.773181 |
| Popis: | Fil: Mul Fedele, Malena Lis. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Cronofisiología; Argentina Fil: Mul Fedele, Malena Lis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Senna, Camila Agustina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina Fil: Senna, Camila Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aiello, Ignacio. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina Fil: Aiello, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Golombek, Diego A. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina Fil: Golombek, Diego A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina Fil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Abstract: Sepsis is a syndrome caused by a deregulated host response to infection, representing the primary cause of death from infection. In animal models, the mortality rate is strongly dependent on the time of sepsis induction, suggesting a main role of the circadian system. In patients undergoing sepsis, deregulated circadian rhythms have also been reported. Here we review data related to the timing of sepsis induction to further understand the different outcomes observed both in patients and in animal models. The magnitude of immune activation as well as the hypothermic response correlated with the time of the worst prognosis. The different outcomes seem to be dependent on the expression of the clock gene Bmal1 in the liver and in myeloid immune cells. The understanding of the role of the circadian systemin sepsis pathology could be an important tool to improve patient therapies. |
| Databáze: | OpenAIRE |
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