Asymmetric Magnesium-Catalyzed Hydroboration by Metal-Ligand Cooperative Catalysis
| Autor: | Alban Falconnet, Marc Magre, Bholanath Maity, Luigi Cavallo, Magnus Rueping |
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| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Reaction mechanism Ketone 010405 organic chemistry Ligand Enantioselective synthesis Context (language use) General Chemistry Nuclear magnetic resonance spectroscopy 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Hydroboration chemistry |
| Zdroj: | Angewandte Chemie (International ed. in English). 58(49) |
| ISSN: | 1521-3773 |
| Popis: | Asymmetric catalysis with readily available, cheap, and non-toxic alkaline earth metal catalysts represents a sustainable alternative to conventional synthesis methodologies. In this context, we describe the development of a first MgII -catalyzed enantioselective hydroboration providing the products with excellent yields and enantioselectivities. NMR spectroscopy studies and DFT calculations provide insights into the reaction mechanism and the origin of the enantioselectivity which can be explained by a metal-ligand cooperative catalysis pathway involving a non-innocent ligand. |
| Databáze: | OpenAIRE |
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