Evaluation of changes in the serum levels of Krebs von den Lungen-6 and surfactant protein-D over time as important biomarkers in idiopathic fibrotic nonspecific interstitial pneumonia
| Autor: | Erina Tabata, Eri Hagiwara, Koji Okudela, Ryo Okuda, Hideaki Yamakawa, Shinichiro Iso, Satoshi Ikeda, Ryota Otoshi, Akimasa Sekine, Tomohisa Baba, Tae Iwasawa, Tamiko Takemura, Takashi Ogura |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Vital capacity Time Factors Disease Gastroenterology Pulmonary function testing 03 medical and health sciences Idiopathic pulmonary fibrosis FEV1/FVC ratio 0302 clinical medicine DLCO Predictive Value of Tests Diffusing capacity Internal medicine medicine Humans 030212 general & internal medicine Idiopathic Interstitial Pneumonias Aged Retrospective Studies Lung business.industry Mucin-1 respiratory system Middle Aged medicine.disease Pulmonary Surfactant-Associated Protein D Idiopathic Pulmonary Fibrosis medicine.anatomical_structure 030228 respiratory system Disease Progression Female business Biomarkers |
| Zdroj: | Respiratory investigation. 57(5) |
| ISSN: | 2212-5353 |
| Popis: | Background Some cases of idiopathic fibrotic nonspecific interstitial pneumonia (f-NSIP) show a progressive course that is similar to that of idiopathic pulmonary fibrosis. However, it is difficult to predict poor patient outcomes. This study aimed to evaluate whether serial changes in serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) can predict disease progression. Methods We retrospectively analyzed the medical records of 75 patients with idiopathic f-NSIP. Disease behavior was categorized into two groups depending on long-term change of pulmonary function: progressive type (≥5%/year relative decline in the slope of forced vital capacity [FVC] and/or ≥7.5%/year relative decline in the slope of %diffusing capacity of the lung for carbon monoxide [%DLCO]) and stable type. Levels of KL-6 and SP-D and results of pulmonary function tests, which were performed parallelly, were reviewed and analyzed using a linear mixed-effects model. Results The study subjects comprised 62 patients with stable type and 13 patients with progressive type disease behavior. Among these subjects, 50 patients fulfilled the diagnostic criteria of interstitial pneumonia with autoimmune features (IPAF). Serum levels of both KL-6 and SP-D at baseline showed a negative correlation with %DLCO, but not with FVC, and these biomarkers were not related to disease progression. Persistently high levels of KL-6 and SP-D correlated with progressive type disease behavior in idiopathic (non-IPAF) f-NSIP. Conclusions Changes in serum KL-6 and SP-D levels over time may provide useful predictive information on disease behavior during treatment in patients with idiopathic f-NSIP and especially in those with non-IPAF f-NSIP. |
| Databáze: | OpenAIRE |
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