A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population
| Autor: | Hideaki Masuzaki, Shoko Miura, Hiroyuki Mishima, Masanori Kaneuchi, Kiyonori Miura, Michio Kitajima, Koh-ichiro Yoshiura, Shuhei Abe, Ai Higashijima, Michio Yasunami, Naoki Fuchi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Risk 0301 basic medicine Oncology China medicine.medical_specialty Genotype Quantitative Trait Loci Uterine Cervical Neoplasms Genome-wide association study Biology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Japan Internal medicine Odds Ratio Genetics medicine Humans Genetic Predisposition to Disease Neoplasm Invasiveness Alleles HLA-DP beta-Chains Genetics (clinical) Aged Cervical cancer Case-control study Odds ratio Middle Aged medicine.disease 030104 developmental biology Genetic epidemiology Statistical genetics Case-Control Studies 030220 oncology & carcinogenesis Medical genetics Female Chromosomes Human Pair 17 Genome-Wide Association Study |
| Zdroj: | Journal of Human Genetics. 61:793-796 |
| ISSN: | 1435-232X 1434-5161 |
| Popis: | In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population. Human leukocyte antigen (HLA)-DPB1 alleles were also investigated for their association with cervical cancer risk in the Japanese population. After receiving written informed consent, 214 unrelated Japanese women with invasive cervical cancer and 288 cancer-free Japanese women were recruited, and DNA samples were obtained (study protocol approved by Institutional Review Board of Nagasaki University). Of the four single-nucleotide polymorphisms, rs8067378 showed a significant association with invasive cervical cancer (P=0.0071). Under a recessive model, the minor allele G of rs8067378 contributed to the risk of invasive cervical cancer (odds ratio=2.92, 95% confidence interval=1.40-6.36; P=0.0021). No association was detected between HLA-DPB1 alleles and cervical cancer risk in the Japanese population. In conclusion, we show for the first time, to the best of our knowledge, that an association between increased risk of invasive cervical cancer and rs8067378 in the Han Chinese population is replicated in a Japanese population. In addition, Japanese women with the GG genotype of rs8067378 are a candidate high-risk group for invasive cervical carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink