Arene ruthenium(II) Complexes: The Promising Chemotherapeutic Agent in Inhibiting the Proliferation, Migration and Invasion
| Autor: | Qiong Wu, Wenjie Mei, Kangdi Zheng, Yang Ding |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Angiogenesis
Stereochemistry chemistry.chemical_element Antineoplastic Agents Apoptosis 02 engineering and technology 010402 general chemistry Hydrocarbons Aromatic 01 natural sciences Ruthenium Cell Movement Coordination Complexes In vivo Neoplasms Drug Discovery Animals Humans Neoplasm Invasiveness Cell Proliferation Pharmacology Low toxicity Biological activity Cell Cycle Checkpoints General Medicine 021001 nanoscience & nanotechnology In vitro 0104 chemical sciences chemistry Cancer research 0210 nano-technology |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 16:796-803 |
| ISSN: | 1389-5575 |
| Popis: | Arene ruthenium(II) complexes have been widely investigated as one of the most promising candidates in chemotherapy because of their low toxicity and high inhibiting activity against the proliferation, invasion, migration, and angiogenesis of various tumors in vitro and in vivo. This review highlights the recent developments in different chemical types of arene Ru(II) complexes, as well as their biological activity and underlying mechanisms. The sustained efforts in this aspect of arene Ru(II) complexes would be essential in developing novel anti-tumor agents in the near future. |
| Databáze: | OpenAIRE |
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