Soleus muscle alterations in spontaneously hypertensive rats are not dependent on activation of β2-adrenergic receptors
| Autor: | Roland Favier, M. H. Mayet, J. M. Cottet-Emard, L. Benbachir-Lamrini, Harry Koubi, J. Frutoso, B. Sempore |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Thyroid Hormones medicine.medical_specialty Physiology Adrenergic beta-Antagonists Oxidative phosphorylation Biology Rats Inbred WKY β2 adrenergic receptor Propanolamines Contractility Catecholamines Rats Inbred SHR Internal medicine medicine Animals Distribution (pharmacology) Glycolysis Soleus muscle Histocytochemistry Adrenergic blockade Muscles General Neuroscience Hindlimb Rats Blockade Endocrinology Regional Blood Flow Hypertension Female Receptors Adrenergic beta-2 Neurology (clinical) Muscle Contraction |
| Zdroj: | Journal of the Autonomic Nervous System. 44:161-170 |
| ISSN: | 0165-1838 |
| Popis: | The effects of selective β 2 -adrenergic blockade with ICI 118,551 on the histochemical, biochemical, and contractile properties of slow-twitch soleus muscle from spontaneously hypertensive (SHR) and normotensive (WKY) rats were examined from birth to 8–10 weeks of age. Chronic treatment of normotensive rats with ICI 118,551 caused an impairment in the differentiation of slow type fibers during development but failed to alter the fiber type distribution of hypertensive rats, β 2 -Adrenoreceptor blockade was ineffective in reducing the enhanced glycolytic and oxidative capacities of soleus in hypertensive rats. The suggestion can be made that β 2 -adrenoreceptor activation is not responsible, at least directly, for the histochemical and biochemical alterations of slow muscle from hypertensive rats. |
| Databáze: | OpenAIRE |
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