Executive Function Declines in the First 6 Months After a Transient Ischemic Attack or Transient Neurological Attack
| Autor: | Edo Richard, Sarah E. Vermeer, Bozena Goraj, Peter J. Koudstaal, Ewoud J. van Dijk, Frank G. van Rooij, Roy P. C. Kessels, Nicole O. Plaizier, Frank-Erik de Leeuw |
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| Přispěvatelé: | Neurology |
| Rok vydání: | 2017 |
| Předmět: |
Male
Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] 030204 cardiovascular system & hematology Neuropsychological Tests Cohort Studies Executive Function 0302 clinical medicine Cognition Attention Episodic memory Stroke Aged 80 and over medicine.diagnostic_test Middle Aged Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Cognitive test Ischemic Attack Transient Cardiology Disease Progression Female medicine.symptom Cardiology and Cardiovascular Medicine Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] medicine.medical_specialty Memory Episodic Lesion 03 medical and health sciences Internal medicine medicine Reaction Time Dementia Humans Effects of sleep deprivation on cognitive performance cardiovascular diseases Aged Advanced and Specialized Nursing Neuro- en revalidatiepsychologie business.industry Neuropsychology and rehabilitation psychology Magnetic resonance imaging Plasticity and Memory [DI-BCB_DCC_Theme 3] medicine.disease Diffusion Magnetic Resonance Imaging Physical therapy Neurology (clinical) Nervous System Diseases business 030217 neurology & neurosurgery |
| Zdroj: | Stroke, 48, 3323-3328 Journal of the American Heart Association, 48(12), 3323-3328. Wiley Stroke, 48, 12, pp. 3323-3328 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background and Purpose— Although by definition transient, both transient ischemic attack (TIA) and transient neurological attack (TNA) are associated with cognitive impairment. Determinants and course of cognitive function afterward are, however, unclear. We prospectively determined cognitive performance after TIA and TNA in relation to clinical diagnosis and diffusion-weighted imaging (DWI) results. Methods— TIA and TNA patients aged ≥45 years without prior stroke or dementia underwent comprehensive cognitive assessment and magnetic resonance imaging within 7 days after the qualifying event. Cognitive tests were repeated after 6 months. Domain-specific compound z scores based on the baseline mean and SD were calculated. Repeated-measures analysis was used to test for differences in domain-specific cognitive performance over time between DWI-positive and DWI-negative patients, as well as between TIA and TNA patients. Results— One hundred twenty-one patients were included (mean age (SD), 64.6 years (9.2 years), 60% TIA and 40% TNA) of whom 32 (26%) had a DWI lesion. Executive function performance decreased over time (mean change in compound score −0.23; P =0.01 adjusted for age, sex, education), whereas attention improved (0.11; P =0.02), and information processing speed and episodic memory remained unchanged. Patients with a DWI lesion had worse executive function at baseline than those without a DWI lesion (compound scores −0.26 versus 0.08; P =0.048), which persisted throughout the study period ( P =0.04). Clinical diagnosis (TIA or TNA) was not related to cognitive function over time. Conclusions— Executive function declines during the first 6 months after TIA or TNA. Patients with an initial DWI lesion have persisting worse executive function than those without. |
| Databáze: | OpenAIRE |
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