Cytogenetic Profile of Unknown Primary Tumors: Clues for Their Pathogenesis and Clinical Management
| Autor: | Nikos Pandis, Georgia Bardi, Theoni Trangas, Sophia Markidou, Anna Papadopoulou, Nikiforos Apostolikas, Haroula Tsarouha, Louiza Mahaira, Ioannis Kyriazoglou, Dimitra Pantou |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chromosome abnormalities
Cancer Research medicine.medical_specialty Pathology medicine.diagnostic_test Cytogenetics Chromosome Karyotype differential diagnosis and prognosis Biology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 cancer of unknown primary Chromosome regions medicine Adenocarcinoma Differential diagnosis DNA copy number changes metastasis of unknown primary Comparative genomic hybridization Fluorescence in situ hybridization |
| Zdroj: | Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 1, Pp 23-31 (2003) |
| ISSN: | 1476-5586 |
| DOI: | 10.1016/s1476-5586(03)80014-3 |
| Popis: | Unknown primary tumors (UPTs) represent an entity of great clinical and biological interest, whose origin cannot be determined even after medical workup. To better understand their pathogenesis by outlining their genetic composition, 20 UPTs were investigated by G-banding, supplemented with Fluorescence In Situ Hybridization and Comparative Genomic Hybridization analyses. The data obtained were sufficient to reach a diagnosis in five cases—four lymphomas and one Ewing sarcoma—demonstrating that in a subset of UPTs, cytogenetics can be an adjunct for differential diagnosis. In the remaining 15 UPTs, an aggressive cytogenetic pattern was revealed. The most frequently rearranged chromosome regions were 1q21, 3p13, 6q15-23, 7q22, 11p12-5, and 11q14-24, pinpointing gene loci probably associated with the peculiar pathogenesis of UPTs. The preferential involvement of 4q31, 6q15, 10q25, and 13q22 in adenocarcinomas (whereas 11q22 is involved in the rest of the carcinomas)—in addition to the marked divergence in the mean average of chromosomal changes, 16 and 3, respectivelydemonstrates genotypic differences between the two histologic subgroups. Furthermore, the significantly shorter survival in cases displaying massive chromosome changes compared with those having a few changes indicates that the cytogenetic pattern might be used as a tool to assess prognosis in UPTs, even without the detection of their primary site. |
| Databáze: | OpenAIRE |
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