Dynamic neurocognitive changes in interoception after heart transplant
| Autor: | Adolfo M. García, Margarita Peradejordi, Roberto R. Favaloro, Agustín Ibáñez, Paula Salamone, Tristan A. Bekinschtein, Daniel O. Absi, Liliana E. Favaloro, Agustina Legaz, Lucas Sedeño, Nicolas Rodriguez Arriagada, Matías Fraile-Vazquez, Federico Adolfi, Miguel Martorell |
|---|---|
| Přispěvatelé: | Bekinschtein, Tristan [0000-0001-5501-8628], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Longitudinal study Heartbeat medicine.medical_treatment vagus nerve denervation heart transplantation interoception 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Internal medicine HEARTBEAT EVOKED POTENTIAL medicine 0501 psychology and cognitive sciences Evoked potential Heart transplantation VAGUS NERVE DENERVATION AcademicSubjects/SCI01870 business.industry 05 social sciences General Engineering purl.org/becyt/ford/3.1 [https] INTEROCEPTION HEARTBEAT DETECTION Transplantation Electrophysiology HEART TRANSPLANTATION Cardiology Interoception Original Article AcademicSubjects/MED00310 purl.org/becyt/ford/3 [https] heartbeat detection business Neurocognitive heartbeat evoked potential 030217 neurology & neurosurgery |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Brain Communications |
| ISSN: | 2632-1297 |
| Popis: | Heart–brain integration dynamics are critical for interoception (i.e. the sensing of body signals). In this unprecedented longitudinal study, we assessed neurocognitive markers of interoception in patients who underwent orthotopic heart transplants and matched healthy controls. Patients were assessed longitudinally before surgery (T1), a few months later (T2) and a year after (T3). We assessed behavioural (heartbeat detection) and electrophysiological (heartbeat evoked potential) markers of interoception. Heartbeat detection task revealed that pre-surgery (T1) interoception was similar between patients and controls. However, patients were outperformed by controls after heart transplant (T2), but no such differences were observed in the follow-up analysis (T3). Neurophysiologically, although heartbeat evoked potential analyses revealed no differences between groups before the surgery (T1), reduced amplitudes of this event-related potential were found for the patients in the two post-transplant stages (T2, T3). All these significant effects persisted after covariation with different cardiological measures. In sum, this study brings new insights into the adaptive properties of brain–heart pathways. Salamone et al. report longitudinal evidence of heart–brain dynamics during interoceptive processing in patients with heart transplants and matched controls. Results show neurocognitive changes in interoception (modulation of heart-evoked potential and performance) after heart transplant, suggesting a role of vagal pathways in cardioception and bringing novel insights into brain–heart communication. Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|