Influence on persistence and adherence with oral bisphosphonates on fracture rates in osteoporosis
| Autor: | Guido Schiffhorst, Cornelia Seidlitz, Bertram Häussler, Ariane Höer, Melvin Olson, Holger Gothe, Peyman Hadji |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Continuous therapy
Fracture risk medicine.medical_specialty fracture risk Orales Arzneimittel Osteoporosis Medicine (miscellaneous) compliance Persistence (computer science) Internal medicine medicine oral bisphosphonates ddc:610 Medical prescription Osteoporose Pharmacology Toxicology and Pharmaceutics (miscellaneous) Persistenz Original Research Oral bisphosphonates Proportional hazards model business.industry Health Policy Knochenbruch persistence medicine.disease Surgery Medication possession ratio 610 Medizin Gesundheit Diphosphonate Patient Preference and Adherence business Social Sciences (miscellaneous) |
| Zdroj: | Patient preference and adherence |
| DOI: | 10.25968/opus-2731 |
| Popis: | Ariane Höer1, Cornelia Seidlitz1, Holger Gothe1, Guido Schiffhorst1, Melvin Olson2, Peyman Hadji3, Bertram Häussler11IGES Institut, Friedrichstrasse 180, D-10117 Berlin, Germany; 2Novartis Pharma AG; 3Department of Gynaecology, University hospital of Giessen and Marburg GmbH, Marburg, GermanyBackground and Aim: Oral bisphosphonates have been shown to reduce the risk of fractures in patients with osteoporosis. It can be assumed that the clinical effectiveness of oral bisphosphonates depends on persistence with therapy.Methods: The influence of persistence with and adherence to oral bisphosphonates on fracture risk in a real-life setting was investigated. Data from 4451 patients with a defined index prescription of bisphosphonates were included. Fracture rates within 180, 360, and 720 days after index prescription were compared between persistent and non-persistent patients. In an extended Cox regression model applying multiple event analysis, the influence of adherence was analyzed. Persistence was defined as the duration of continuous therapy; adherence was measured in terms of the medication possession ratio (MPR).Results: In patients with a fracture before index prescription, fracture rates were reduced by 29% (p = 0.025) comparing persistent and non-persistent patients within 180 days after the index prescription and by 45% (p |
| Databáze: | OpenAIRE |
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