Precise Holographic Manipulation of Olfactory Circuits Reveals Coding Features Determining Perceptual Detection
| Autor: | Dmitry Rinberg, Shy Shoham, Gilad M. Lerman, Benjamin J. Stetler, Hetince Zhao, Jonathan V. Gill |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Holography Action Potentials Sensory system Stimulation Olfaction Optogenetics Biology Stimulus (physiology) Photostimulation 03 medical and health sciences 0302 clinical medicine Two-photon excitation microscopy Animals Neurons General Neuroscience Optical Imaging Olfactory Perception Olfactory Bulb Olfactory bulb Mice Inbred C57BL Smell 030104 developmental biology nervous system Sensory Thresholds Odorants Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron. 108:382-393.e5 |
| ISSN: | 0896-6273 |
| Popis: | Sensory systems transform the external world into time-varying spike trains. What features of spiking activity are used to guide behavior? In the mouse olfactory bulb, inhalation of different odors leads to changes in the set of neurons activated, as well as when neurons are activated relative to each other (synchrony) and the onset of inhalation (latency). To explore the relevance of each mode of information transmission, we probed the sensitivity of mice to perturbations across each stimulus dimension (i.e., rate, synchrony, and latency) using holographic two-photon optogenetic stimulation of olfactory bulb neurons with cellular and single-action-potential resolution. We found that mice can detect single action potentials evoked synchronously across |
| Databáze: | OpenAIRE |
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