COVID-19 and the human innate immune system
| Autor: | Joachim L. Schultze, Anna C. Aschenbrenner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Population Review Disease immunosuppressive cells Biology Severity of Illness Index General Biochemistry Genetics and Molecular Biology 03 medical and health sciences trained immunity 0302 clinical medicine Immune system Pandemic Humans immunology [COVID-19] genetics ddc:610 education innate immunity 030304 developmental biology physiology [SARS-CoV-2] 0303 health sciences education.field_of_study Innate immune system Host Microbial Interactions SARS-CoV-2 pandemic COVID-19 granulocytes interferon biochemical phenomena metabolism and nutrition Causality Immunity Innate 3. Good health viral sepsis Immunology monocytes 030217 neurology & neurosurgery |
| Zdroj: | Cell 184(7), 1671-1692 (2021). doi:10.1016/j.cell.2021.02.029 Cell |
| DOI: | 10.1016/j.cell.2021.02.029 |
| Popis: | The introduction of SARS-CoV-2 into the human population represents a tremendous medical and economical crisis. Innate immunity - as the first line of defense of our immune system - plays a central role in combating this novel virus. Here, we provide a conceptual framework for the interaction of the human innate immune system with SARS-CoV-2 to link the clinical observations with experimental findings that have been made during the first year of the pandemic. We review evidence that variability in innate immune system components among humans is a main contributor to the heterogeneous disease courses observed for COVID-19, the disease spectrum induced by SARS-CoV-2. A better understanding of the pathophysiological mechanisms observed for cells and soluble mediators involved in innate immunity is a prerequisite for the development of diagnostic markers and therapeutic strategies targeting COVID-19. However, this will also require additional studies addressing causality of events, which is so far lacking behind. Differences in innate immune system function may underpin the curiously variable disease spectrum of COVID-19. |
| Databáze: | OpenAIRE |
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