Expression of IFITM1 as a prognostic biomarker in resected gastric and esophageal adenocarcinoma
| Autor: | Richard Fristedt, David Borg, Anders Johnsson, Alexander Gaber, Jakob Eberhard, Charlotta Hedner, Björn Nodin, Karin Jirström |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty medicine.medical_treatment Stomach neoplasms Clinical Biochemistry Adenocarcinoma 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Lymph node Neoadjuvant therapy Tissue microarray business.industry Research Biochemistry (medical) Cancer Intestinal metaplasia Esophageal cancer Prognosis medicine.disease IFITM1 030104 developmental biology medicine.anatomical_structure Esophageal neoplasms 030220 oncology & carcinogenesis Molecular Medicine Immunohistochemistry business |
| Zdroj: | Biomarker Research |
| ISSN: | 2050-7771 |
| Popis: | Background There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic significance in gastroesophageal adenocarcinoma. Methods Tissue samples were obtained from a consecutive cohort of 174 patients surgically treated between 2006 and 2010 for gastroesophageal (gastric, gastroesophageal junction and esophageal) adenocarcinoma, not subjected to neoadjuvant therapy. Expression of IFITM1 was examined using immunohistochemistry on tissue microarrays of primary tumors and paired samples of adjacent normal epithelium, intestinal metaplasia and lymph node metastases. Results Expression of IFITM1 was significantly elevated in primary tumors and lymph node metastases compared to adjacent normal epithelium and intestinal metaplasia, regardless of tumor location. Overexpression of IFITM1 was associated with M0-disease (no distant metastases). In gastric cancer IFITM1 expression was significantly associated with improved TTR (time to recurrence) in Kaplan-Meier analysis and Cox regression, both in the unadjusted analysis (HR 0.33, 95 % CI 0.12-0.88) and in the adjusted analysis (HR 0.32, 95 % CI 0.12-0.87) but there was no significant impact on OS (overall survival). In esophageal adenocarcinoma expression of IFITM1 had no impact on TTR or OS in Kaplan-Meier-analyses, but in the adjusted Cox regression IFITM1 expression had a negative impact on both TTR (HR 3.05, 95 % CI 1.09-8.53) and OS (HR 2.71, 95 % CI 1.11-6.67). Conclusions IFITM1 was overexpressed in gastroesophageal adenocarcinoma and associated with M0-disease. In gastric cancer IFITM1 expression had a positive impact on TTR but in esophageal cancer it seemed to have an adverse impact on survival. The reason for the diverging prognostic impact of IFITM1 in esophageal and gastric cancer is unclear and warrants further studies. Electronic supplementary material The online version of this article (doi:10.1186/s40364-016-0064-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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