Pediatric Chronic Rhinosinusitis Histopathology
| Autor: | Gilead Berger, Tatiana Kogan, Miki Paker, Yaniv Ebner, Sivan Berger-Achituv |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Biopsy Population Cell Count Young Adult Fibrosis medicine Humans Eosinophilia Sinusitis Child education Aged Rhinitis Lamina propria education.field_of_study medicine.diagnostic_test business.industry Endoscopy Middle Aged Eosinophil medicine.disease Immunohistochemistry Eosinophils Cellular infiltration Nasal Mucosa Cross-Sectional Studies medicine.anatomical_structure Otorhinolaryngology Chronic Disease Female Surgery Histopathology medicine.symptom business Follow-Up Studies |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 144:85-90 |
| ISSN: | 1097-6817 0194-5998 |
| Popis: | To compare the histopathology and immunohistochemistry of pediatric and adult chronic rhinosinusitis (CRS).Cross-sectional study.University-affiliated hospital.Inflamed sinus-mucosal samples of 16 children (mean age, 11.6 ± 2.9 years) with refractory CRS who underwent endoscopic sinus surgery were studied. Twenty-nine diagnosis-matched adults served as controls. Study analysis covered sinus computed tomography (CT) scores, general pathologic features, eosinophil and T-lymphocyte population, and thickness and integrity of the epithelium.Children had a lower CT score than adults did (P = .005). The inflammatory response of the children, which differed greatly from that of adults, was dominated by cellular infiltration of the lamina propria with chronic inflammatory cells and fibrosis (8/16 had extensive fibrosis); eosinophils were scanty. Adult CRS was characterized by polypoid mucosa and eosinophilia (type A) or glandular hyperplasia (type B). Extensive fibrosis was shown in adult type-B patients (7/13). Assessment of eosinophils in the lamina propria showed marginal statistical significance between children and adults (P = .065). This difference was accentuated when pediatric and adult type A were compared (14.6 ± 25.3 vs 121.5 ± 174.2 cell/mm(2); P = .043). Complete epithelial shedding was less significant in children (9.4% ± 8.2% vs 25.4% ± 15.1%; P.001). The number of lamina propria and epithelial T lymphocytes was similar.The marked differences in the inflammatory response of children and adults with CRS may attest to different pathophysiologic pathways. The significantly reduced epithelial shedding in children is probably associated with diminished tissue eosinophilia. Extensive fibrosis was found in half of adult type-B patients; similar findings were found in children. |
| Databáze: | OpenAIRE |
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