Short-term infection of striped bass Morone saxatilis with Mycobacterium marinum
| Autor: | Lonnie Gonsalves, Jimmy Councilman, Eric B. May, Mark D. Fast, Soo Jin Jeon, John M. Jacobs, Ana Baya, Matt R. Rhodes |
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| Rok vydání: | 2011 |
| Předmět: |
Time Factors
food.ingredient biology Morone saxatilis Mycobacterium Infections Nontuberculous Inflammation Aquatic Science biology.organism_classification Microbiology Fish Diseases Bass (fish) Immune system food Immunology Gene expression Mycobacterium marinum medicine Animals Bass sense organs medicine.symptom Pathogen Ecology Evolution Behavior and Systematics Intracellular |
| Zdroj: | Diseases of Aquatic Organisms. 94:117-124 |
| ISSN: | 1616-1580 0177-5103 |
| DOI: | 10.3354/dao02318 |
| Popis: | Striped bass Morone saxatilis were studied in order to characterize their immune responses over the short term following challenge with Mycobacterium marinum. The expression of immunity-related genes (IL-1beta, TNF-alpha, Nramp and TGF-beta) quickly increased following infection with M. marinum, but these genes were subsequently down-regulated despite the fact that bacterial counts remained high. The number of monocytes and neutrophils also initially increased at 1 d postinfection. This confirms the importance of these types of cells in initial inflammation and mycobacterial infection in striped bass. The phagocytic index of splenic leukocytes over these same time frames did not change significantly following infection. The discrete window in which inflammatory mechanisms were stimulated in striped bass may be related to the intracellular nature of this pathogen. |
| Databáze: | OpenAIRE |
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