A Novel High-Throughput Viscometer
| Autor: | Melissa Mushrush, Daniel L. Dermody, Tzu-Chi Kuo, Laura Dietsche, Don W. Patrick, Brian Orvosh, Paul L. Morabito, Jonathan J. Zieman, Matthew T. Bishop, Suraj S. Deshmukh, Keith Harris |
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| Rok vydání: | 2016 |
| Předmět: |
Microfluidics
Nanotechnology 02 engineering and technology 01 natural sciences Microtiter plate Rheology Process engineering Throughput (business) 010405 organic chemistry Chemistry business.industry Viscosity Pipette Viscometer General Chemistry General Medicine Equipment Design Robotics Models Theoretical 021001 nanoscience & nanotechnology 0104 chemical sciences High-Throughput Screening Assays Shear rate Viscosity (programming) 0210 nano-technology business |
| Zdroj: | ACS combinatorial science. 18(7) |
| ISSN: | 2156-8944 |
| Popis: | A novel, rapid, parallel, and high-throughput system for measuring viscosity of materials under different conditions of shear rate, temperature, time, etc., has been developed. This unique system utilizes the transient flow of a complex fluid through pipettes. This approach offers significant practical advantages over microfluidic-based devices for viscosity screening: no cleanup is required, the method is high throughput (1 h for 100 samples), and only small sample volumes (1 mL) are used. This paper details for the first time the experimental and modeling efforts to implement this mass- and pressure-based viscosity measurement concept as a robust viscosity estimation tool. This approach is very well-suited for viscosity measurements in high-throughput formulation workflows, as it is rapid and parallel and operates directly on samples in various microtiter plate formats. We present systematic experimental observations together with numerical and analytical modeling approaches to characterize instrument capabilities and limitations. The complex transient flow of fluids through these pipettes leads to data-rich pressure profiles. Numerical and analytical modeling is then used to extract viscosity and other rheological parameters from these pressure profiles. We have successfully utilized this viscosity screening tool for a multitude of complex fluids including oils, paints, solvents, and detergents. |
| Databáze: | OpenAIRE |
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